Genetic and Chemical Targeting of the ATPase Complex TIP48 and 49 Impairs Acute Myeloid Leukemia

Researchers showed that loss of Tip49 triggered p53-dependent apoptosis and inhibited leukemia development in vivo. To examine the impact of chemical inhibition of this complex on leukemia, they developed the novel compound DS-4950, which interferes with the ATPase activity of the Tip48/49.