Affinity-Selected Heparan Sulfate Collagen Device Promotes Periodontal Regeneration in an Intrabony Defect Model in Macaca fascicularis

The authors previously reported a heparan sulfate variant with enhanced affinity for bone morphogenetic protein-2, termed HS3, that enhanced periodontal tissue regeneration in a rodent model. Theysought to transition this work closer to the clinic and investigate the efficacy of the combination HS3 collagen device in a non-human primate periodontitis model.