Young Glial Progenitor Cells Competitively Replace Aged and Diseased Human Glia in the Adult Chimeric Mouse Brain

To investigate whether healthy glia can outcompete diseased human glia in the adult forebrain, scientists engrafted wild-type human glial progenitor cells (hGPCs) produced from human embryonic stem cells into the striata of adult mice that had been neonatally chimerized with mutant Huntingtin-expressing hGPCs.