Zfp296 Knockout Enhances Chromatin Accessibility and Induces a Unique State of Pluripotency in Embryonic Stem Cells

Transcriptome analysis revealed that Zfp296 deficiency in Zfp296-knockout ESCs up- and down-regulated a distinct group of genes, among which Dppa3, Otx2, and Pou3f1 were markedly downregulated.