Fgf9-Nolz-1-Wnt2 Axis Regulates Morphogenesis of the Lung Icon for the Forest of Biologists

Scientists identified Nolz-1/Znf503 as a mesenchymal lineage-specific transcriptional regulator that plays a key role in lung morphogenesis. Nolz-1 null mutation resulted in a severe hypoplasia phenotype, including a decreased proliferation of mesenchymal cells, aberrant differentiation of epithelial cells, and defective growth of epithelial branches