CD44 Mediated Colon Cancer Targeting Mutlifaceted Lignin Nanoparticles: Synthesis, In Vitro Characterization and In Vivo Efficacy Studies

Cell anti-proliferation and mitochondrial depolarization studies on HT-29 cells suggest significantly improved chemotherapeutic efficacy of hyaluronic acid-coated irinotecan loaded lignin nanoparticles. In vitro cell-based studies showed that nanoparticles have retained the antioxidant activity of lignin that can prevent cancer relapse.