T Cell Deletional Tolerance Restricts AQP4 but Not MOG CNS Autoimmunity

When modeling neuromyelitis optica, only aquaporin-4 (AQP4)-reactive Th17 cells from AQP4-deficient, but not wild-type mice, caused central nervous system autoimmunity in recipient wildtype mice, indicating that a tightly regulated mechanism normally ensured tolerance to AQP4.