Both Intratumoral Regulatory T Cell Depletion and CTLA-4 Antagonism Are Required for Maximum Efficacy of Anti-CTLA-4 Antibodies

By
Laurisa Dohm
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0
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Scientists reported the engineering of a nonantagonistic CTLA-4 binding domain that depleted intratumoral Tregs as an Fc fusion.
[Proceedings Of The National Academy Of Sciences Of The United States Of America]
Abstract