Keratinocytes-Specific SOX2 Overexpression Suppressed Pressure Ulcer Formation Following Cutaneous I/R Injury via Enhancement of Amphiregulin Production

Ulcer formation was significantly suppressed in keratinocytes-specific SOX2-overexpressing mice. SOX2 in skin keratinocytes significantly suppressed the infiltrating inflammatory cells, apoptotic cells, vascular damage, and hypoxic areas in cutaneous Ischemia-reperfusion injury.