Schwann Cells Regulate Tumor Cells and Cancer-Associated Fibroblasts in the Pancreatic Ductal Adenocarcinoma Microenvironment

In vitro and in vivo assays demonstrated that Schwann cells enhanced the proliferation and migration of PDAC cells via Midkine signaling, and promoted the switch of cancer-associated fibroblasts (CAFs) to basal-like and inflammatory CAFs via interleukin-1α.