Comparison of Infection and Human Immune Responses of Two SARS-CoV-2 Strains in a Humanized hACE2 NIKO Mouse Model

Researchers described a humanized human angiotensin-converting enzyme-2 (hACE2) NOD-SCID IL2Rγ−/− (NIKO) mouse model and compared infection with ancestral and mutant strains of SARS-CoV-2.