Human Anti-N1 Monoclonal Antibodies Elicited by Pandemic H1N1 Virus Infection Broadly Inhibit HxN1 Viruses In Vitro and In Vivo

The monoclonal antibodies provided robust protection from lethal challenge with human H1N1 and avian H5N1 viruses in mice, and both targeted an epitope on the lateral face of neuraminidase.