Skp2-Mediated MLKL Degradation Confers Cisplatin-Resistant in Non-small Cell Lung Cancer Cells

Scientists discovered that the E3 ligase Skp2 is overexpressed, accompanied by the downregulation of necroptosis-related regulator MLKL in human NSCLC tissues and cell lines. Knockdown of Skp2 inhibited viability, anchorage-independent growth, and in vivo tumor development of NSCLC cells.