Thiol–Disulfide Exchange Coordinates the Release of Nitric Oxide and Dexamethasone for Synergistic Regulation of Intestinal Microenvironment in Colitis

Investigators reported the development of thiol–disulfide hybrid mesoporous organosilica nanoparticles that improved the storage and sustained release of nitric oxide (NO), broadening the therapeutic window of NO-based therapy against colitis.