Vitamin D Induces SIRT1 Activation Through K610 Deacetylation in Colon Cancer

Scientists revealed that 1α,25-dihydroxyvitamin D3, the active metabolite of vitamin D, promoted SIRT1 activation through auto-deacetylation in human colon carcinoma cells, and identified lysine 610 as an essential driver of SIRT1 activity.