Circ_0001666 Upregulation Promotes Intestinal Epithelial Cell Fibrosis in Pediatric Crohn’s Disease via the SRSF1/BMP7 Axis

Investigators explored the molecular mechanism of circ_0001666 in regulating epithelial–mesenchymal transition (EMT)-mediated fibrosis in Crohn’s disease (CD) in vitro. The levels of circ_0001666 and EMT-associated proteins were assessed in CD clinical samples, and a CD cell model was established using TGF-β1 to induce human intestinal epithelial cells.