A Bimetallic Nanoplatform for STING Activation and CRISPR/Cas Mediated Depletion of the Methionine Transporter in Cancer Cells Restores Anti-Tumor Immune Responses

Scientists constructed a synergistic nanoplatform to promote CD8+ T cell infiltration in tumors while restoring T cell function by regulating methionine metabolism and activating the STING innate immune pathway.