SQLE Promotes Pancreatic Cancer Growth by Attenuating ER Stress and Activating Lipid Rafts-Regulated Src/PI3K/Akt Signaling Pathway

Scientists found that squalene epoxidase (SQLE) was a crucial mediator of cholesterol metabolism in prostate cancer growth. They observed a profound upregulation of SQLE in prostate cancer tissues, and its high expression was correlated with poor patient outcomes.