IL-2Rα-Biased Agonist Enhances Antitumor Immunity by Invigorating Tumor-Infiltrating CD25+CD8+ T Cells

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Researchers showed that both wild-type and interleukin-2 receptor-β/interleukin-2 receptor-γ (IL-2Rβγ)-attenuated agonists that preserved IL-2Rα activities could effectively expand tumor-specific CD8+ T cells.
[Nature Cancer]
Abstract