Inhibition of EZH2 Alleviates SAHA-Induced Senescence-Associated Secretion Phenotype in Small Cell Lung Cancer Cells

Researchers reported that SCLC cells treated with an FDA-approved HDAC inhibitor SAHA underwent senescence and displayed remarkable senescence-associated secretion phenotype. In particular, SAHA promoted the formation of cytoplasmic chromatin fragments in SCLC cells.