Ezh2 Promotes Mammary Tumor Initiation through Epigenetic Regulation of the Wnt and mTORC1 Signaling Pathways

To gain a deeper understanding of the role of Enhancer of Zeste homology 2 (Ezh2) in the early stages of mammary tumor progression, investigators employed an inducible mammary organoid system bearing conditional Ezh2 alleles that faithfully recapitulated key events of luminal B breast cancer initiation.