A Comprehensive Appraisal of HER2 Heterogeneity in HER2-Amplified and HER2-Low Colorectal Cancer

Researchers elucidated the clinicopathological and molecular features of HER2-amplified and HER2-low colorectal cancers (CRCs). They also characterized HER2 expression statuses in CRCs focusing on their intratumoral heterogeneity and alterations in metastatic lesions to establish practical HER2 status assessment.