SMAD2 Inhibits Pyroptosis of Fibroblast-Like Synoviocytes and Secretion of Inflammatory Factors via the TGF-β Pathway in Rheumatoid Arthritis

Researchers collected synovial tissues of RA patients and FLS-RA and cultured FLS for detection of expression of SMAD2. ASC, NLRP3, cleaved-caspase-1, and GSDMD-N were detected by Western blot after overexpression of SMAD2.