PRMT1 Methylation of Wtap Promotes Multiple Myeloma Tumorigenesis by Activating Oxidative Phosphorylation via m6A Modification of NDUFS6

Researchers found that protein arginine methyltransferase 1 (PRMT1) was highly expressed in multiple myeloma (MM) patients, which was positively correlated with MM stages. They further showed that silencing PRMT1 inhibited MM proliferation and tumorigenesis in vitro and in vivo.