Characterizing the Role of Phlda3 in the Development of Acute Toxicity and Malignant Transformation of Hematopoietic Cells Induced by Total-Body Irradiation in Mice

Using isogenic cell lines and genetically engineered mouse models, investigators showed that radiation induces Phlda3 in human leukemia cells and mouse normal hematopoietic cells in a p53-dependent manner.