High-Throughput Characterization of HLA-E-Presented CD94/NKG2x Ligands Reveals Peptides Which Modulate NK Cell Activation

Utilizing sequences identified via yeast display selections, investigators trained prediction algorithms and identifed human and cytomegalovirus proteome-derived, HLA-E-presented peptides capable of binding and signaling through both CD94/NKG2A and CD94/NKG2C.