Exosomes Secreted by Mesenchymal Stem Cells Delay Brain Aging by Upregulating SIRT1 Expression

Researchers tested the neuroprotective effects of MSC-Exos in vitro on H2O2-induced oxidative damage in BV2 cells. An in vivo SAMP8 rapid senescence mouse model showed that MSC-Exos significantly increased SIRT1 gene expression in senescent mice.