tRNA-Derived Small RNA Changes in Bone Marrow Stem Cells under Hypoxia and Osteogenic Conduction

Scientists employed bone MSCs (BMSCs) obtained from healthy donors and simulated hypoxia using CoCl2 stimulation. High-throughput sequencing technique was used to identify differential expression profiles of tRNA-derived small RNA in three experimental groups: BMSCs-0d, BMSCs-7d, and BMSCs-0d-CoCl2.