CDK7-YAP-LDHD Axis Promotes D-Lactate Elimination and Ferroptosis Defense to Support Cancer Stem Cell-Like Properties

Researchers discovered that cyclin-dependent kinase 7 (CDK7) phosphorylated nuclear Yes-associated protein 1 (YAP) at S127 and S397 sites and enhanced its transcription function, which promoted D-lactate dehydrogenase (LDHD) protein expression.