Establishment of UGT1A1-Knockout Human iPS-Derived Hepatic Organoids for UGT1A1-Specific Kinetics and Toxicity Evaluation

Using hiPSCs, genome editing technology, and organoid technology, investigators generated uridine diphosphate glucuronosyltransferase (UGT) A1-knockout human iPSC hepatocyte-derived liver organoids as a model for UGT1A1-specific kinetics and toxicity evaluation.