Interferon-G-Dependent Interactions between Tissue-Intrinsic γδ T Cells and Tissue-Infiltrating CD8 T Cells Limit Acute Contact Dermatitis

In mice lacking dendritic intraepidermal γδ T cells or lacking IFNγR solely on γδ cells, allergic contact dermatitis (ACD)-elicited CD8 T cells showed enhanced proliferative and effector potentials and reduced motility, collectively associated with exaggerated ACD pathology.