GATA2 Mitotic Bookmarking Is Required for Definitive Hematopoiesis

Investigators addressed mitotic retention of the hemogenic factors GATA2, GFI1B, and FOS during hematopoietic specification. They showed that GATA2 remains bound to chromatin throughout mitosis, in contrast to GFI1B and FOS, via C-terminal zinc finger-mediated DNA binding.