S1P-S1PR3-RAS Promotes the Progression of S1PR3^hi TAL1⁺ T-cell Acute Lymphoblastic Leukemia That Can Be Effectively Inhibited by an S1PR3 Antagonist

By investigating the transcriptome and prognosis of T cell acute lymphoblastic leukemia (T-ALL) from multiple cohorts, researchers found that S1PR3 was highly expressed in a subset of TAL1+ T-ALL, which showed poor outcomes.