Cultivated Autologous Limbal Epithelial Cell (CALEC) Transplantation: Development of Manufacturing Process and Clinical Evaluation of Feasibility and Safety

To treat unilateral limbal stem cell (LSC) deficiency, scientists developed CALEC using an innovative xenobiotic-free, serum-free, antibiotic-free, two-step manufacturing process for LSC isolation and expansion onto human amniotic membrane.