IL-17A/p38 Signaling Pathway Induces Alveolar Epithelial Cell Pyroptosis and Hyperpermeability in Sepsis-Induced Acute Lung Injury by Activating NLRP3 Inflammasome

Investigators explored their roles and underlying mechanisms in sepsis. The amounts of Th17 cells, IL-17A, IL-1β, IL-18, and lipopolysaccharide was significantly elevated in sepsis patients.