Cezanne Promoted Autophagy Through PIK3C3 Stabilization and PIK3C2A Transcription in Lung Adenocarcinoma

Investigators identified Cezanne, a member of the ovarian tumor protease-deubiquitinating family, as an autophagy regulator. Cezanne was highly expressed in Osimertinib-resistant cells, and Cezanne overexpression promoted Osimertinib resistance, while chloroquine, an autophagy inhibitor, reverted this process.