Hypoxia Induces a Glycolytic Complex in Intestinal Epithelial Cells Independent of HIF-1-Driven Glycolytic Gene Expression

Researchers investigated additional mechanisms regulating glycolysis in hypoxia. They observed that intestinal epithelial cells treated with inhibitors of transcription or translation and human platelets maintained the capacity for hypoxia-induced glycolysis, a finding that suggests the involvement of a nontranscriptional component to the hypoxia-induced metabolic switch to a highly glycolytic phenotype.