ASCL2 Induces an Immune Excluded Microenvironment by Activating Cancer-Associated Fibroblasts in Microsatellite Stable Colorectal Cancer

Researchers reported two distinct expression patterns of ASCL2 in proficient mismatch repair or microsatellite stable (pMMR/MSS) and dMMR/MSI-H colorectal cancers (CRCs). ASCL2 was overexpressed in pMMR/MSS CRCs and maintained a stemness phenotype, accompanied by a lower density of tumor-infiltrating lymphocytes than those in dMMR/MSI CRCs. I