NewslettersImmune Regulation NewsIn Vitro Modeling of CD8+ T Cell Exhaustion Enables CRISPR Screening to Reveal a Role for BHLHE40By Laurisa Dohm - August 25, 20230459The authors established an in vitro model of chronic stimulation and benchmarked key phenotypic, functional, transcriptional, and epigenetic features against bona fide in vivo exhausted CD8 T cells.[Science Immunology]Full Article