Endothelial FIS1 DeSUMOylation Protects against Hypoxic Pulmonary Hypertension

The involvement of sentrin-specific protease 1-mediated SUMOylation in mitochondrial remodeling in the pulmonary endothelium was identified in clinical specimens of hypoxia-related pulmonary hypertention, and was verified in human pulmonary artery endothelial cells under hypoxia.