Dual Targeting Ovarian Cancer by Muc16 CAR T Cells Secreting a Bispecific T Cell Engager Antibody for an Intracellular Tumor Antigen WT1

Researchers described an engineered cell with both dual targeting and orthogonal cytotoxic modalities directed against two tumor antigens that are highly expressed on ovarian cancer cells: cell surface Muc16 and intracellular WT1.