Haspin Balances the Ratio of Asymmetric Cell Division Through Wnt5a and Regulates Cell Fate Decisions in Mouse Embryonic Stem Cells

The authors reported that Haspin knockout mouse (m)ESCs had increased ratio of asymmetric cell division, which cumulatively regulated cell fate decisions. Furthermore, Wnt5a was significantly downregulated due to decreased Pax2 in Haspin-KO mESCs.