Divergent Chondro/Osteogenic Transduction Laws of Fibrocartilage Stem Cell Drive Temporomandibular Joint Osteoarthritis in Growing Mice

Lineage tracing using Gli1-CreER+; Tmfl/- mice and Sox9-CreER+;Tmfl/- mice showed that anterior disc displacement interfered with the chondrogenic capacity of Gli1+ fibrocartilage stem cells as well as osteogenic differentiation of Sox9+ lineage, mainly in the middle zone of temporomandibular joint cartilage.