Impact of PNPLA3 I148M on Alpha-1 Antitrypsin Deficiency-Dependent Liver Disease Progression

After generating transgenic mice that overexpressed the PiZ variant and simultaneously harbored the patatin-like phospholipase domain-containing protein 3 (PNPLA3)I148M knockin, scientists observed that PiZ and PiZ/PNPLA3I148M animals showed increased liver enzymes compared to controls during aging.