SEL1L Preserves CD8⁺ T-Cell Survival and Homeostasis by Fine-Tuning PERK Signaling and the IL-15 Receptor-Mediated mTORC1 Axis

Investigators found that SEL1L deficiency led to a greatly reduced frequency and number of mature T cells, which was further validated by adoptive transfer experiments or bone marrow chimera experiments, accompanied by the induction of multiple forms of cell death.