Acquired miR-142 Deficit in Leukemic Stem Cells Suffices to Drive Chronic Myeloid Leukemia into Blast Crisis

Investigators showed lower levels of miR-142 in CD34+CD38− blasts from blast crisis (BC) chronic myeloid leukemia (CML) patients than in those from chronic phase CML patients, suggesting that miR-142 deficit was implicated in BC evolution.