Targeting NLRP3 Inflammasome for Neurodegenerative Disorders

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Scientists review the mechanisms of NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) expression and activation and discussed the role of active NLRP3 inflammasome in the pathogenesis of neurodegenerative diseases, particularly focusing on Alzheimer’s disease.
[Molecular Psychiatry]
Abstract