Analysis of Local Extracellular Matrix Identifies Different Aetiologies behind Bicuspid and Tricuspid Aortic Valve Degeneration and Suggests Therapies

Researchers compared abundances of ECM proteins from excised valve tissues of 88 patients with isolated aortic valve degeneration (AVD) of normal tricuspid and congenital bicuspid aortic valves, quantified more than 1400 proteins per ECM sample by mass spectrometry, and demonstrated that local ECM preserved molecular cues of the pathophysiological processes.