CUL4B Functions as a Tumor Suppressor in KRAS-Driven Lung Tumors by Inhibiting the Recruitment of Myeloid-Derived Suppressor Cells

Investigators used both autochthonous and transplantable KRAS-mutant tumor models to investigate the role of tumor-derived CUL4B in KRAS-driven lung cancers. We showed that knockout or knockdown of CUL4B promotes lung adenocarcinoma growth and progression in both models.