A Tissue-Intrinsic IL-33/EGF Circuit Promotes Epithelial Regeneration After Intestinal Injury

Utilizing radiation injury to model intestinal pathology, scientists reported that the Interleukin-33 (IL-33)/ST2 axis, an immunomodulatory pathway monitored clinically as an intestinal injury biomarker, regulated intrinsic epithelial regeneration by inducing production of epidermal growth factor (EGF).